Get to know our Workpackages
Development of the
Led by Professor Lino Ferreira from Universidade de Coimbra (Portugal), the main goal of this work package is the design, fabrication and characterization of the 3D-theramesh to locally deliver therapeutics for SCI. This mesh will be then converted into a printable hydrogel formulation, with a major emphasis in the best mechanical properties. New therapeutic nanocarriers systems will be developed for the first line of treatment in the injury environment.
Biocompatibility, biodegradability and functionality in vitro
Active implantable device for on-demand release
Involved Partners: IIT, CSIC, CNC, Black Drop, SESCAM, UCLouvain
in vivo: Evaluation in paralyzed rats
Led by Dr. Juliana M. Rosa from the Hospital Nacional de Parapléjicos (SESCAM, Spain), the main goal of this work package is the in-vivo evaluation of the effects of the 3D-theramesh and motor training protocols independently applied in paralyzed rats. Biocompatibility and biodegradability of the 3D-theramesh will be first evaluated in subcutaneous pockets followed by examination at the injured spinal cord.
Reversion of SCI impairments by multiscale actuation in paralyzed rats
Led by Professor Ricardo García from the Institute of Materials Science in Madrid (CSIC, Spain), the main goal of this work package is the in-vivo demonstration of the therapeutic capabilities of the multiscale and multifaceted therapy. It will involve the identification of functional improvements by conventional immunofluorescence, atomic force microscopy, electrophysiology, and imaging tools.
Dissemination, Exploitation, Research transfer into innovation
All partners involved …
Led by Dr. Katharina Schwaiger from acib (Austria), the main goal of this work package is the dissemination and exploitation of the project and its results including intellectual property. It will include the design and maintenance of the website, the creation of the logo, and the organization, participation and involvement in a diversity of dissemination and exploitation activities including outreach.
Coordination and management
All partners involved …
Led by Dr. M. Concepción Serrano from the Institute of Materials Science in Madrid (CSIC, Spain), the main goal of this work package is the coordination and management of the project and mediation in effective partners’ relationships. It will focus on the elaboration and updating of all the documents that will serve to manage the project and its results and to support reporting to the European Innovation Council along its duration.
M. Concepción Serrano