Main role in the project:
- Determine the role of cortical and thalamic astrocytes in the processing of sensory information in health and after traumatic CNS injuries.
- Study the relationship between alterations in local neuronal circuits within somatosensory cortical and thalamic regions and the appearance of sensory pathologies associated to traumatic spinal cord and brain injury.
- Explore and develop new strategies to manipulate the astrocyte-neuron interaction to promote neural circuits repair and functional recovery after CNS injuries.
The Laboratory of Interfaces for Neural Repair (LINER) was born as an independent research laboratory in the Hospital Nacional de Parapléjicos in January, 2017. LINER research focuses on the design and development of new biomaterials useful to serve as interfaces with the injured central neural tissue and able to represent novel therapeutic alternatives for the treatment of spinal cord injury (SCI). Among the materials currently under investigation, both graphene oxide due to its extraordinary physic-chemical properties and natural polymers (e.g. chitosan, gelatin, hyaluronic acid) due to their high biocompatibility deserve special attention.
In July, 25th, 2017, they created the Joint Research Unit “Design and development of biomaterials for neural repair” between the National Hospital for Paraplegics and the Institute of Materials Science in Madrid (CSIC). Through this unit, they maintain an intensive collaboration between LINER and the Group of Materials for Medicine and Biotechnology (MAMBIO) from the ICMM-CSIC, of which Dr. M. Concepción Serrano is a member (Piezo4Spine coordinator).